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Arsenal exacted revenge against Liverpool on Sunday, Everton kept a dream alive for their manager and Sheffield United caused a dramatic old-fashioned upset as they all reached the FA Cup quarter-finals.
Manchester United and Liverpool, England's two most successful clubs, will do battle in the third round of the FA Cup after the draw was made on Sunday.
Minor league Lincoln City produced a huge FA Cup shock to beat top-flight Burnley 1-0 and reach the quarter-finals for the first time in their history on Saturday.
Liverpool secured a dominant win over West Ham, while other Premier League matches saw Brentford edge Burnley in a seven-goal thriller and Everton secure a late victory against Newcastle.
Tottenham have not won any silverware since they beat Chelsea in the 2008 League Cup final.
A brilliant goal by Demba Ba gave Chelsea a 1-0 win over Manchester United in an FA Cup sixth-round replay at Stamford Bridge on Monday, securing the holders a semi-final against Manchester City.
Manchester City's Argentina striker Carlos Tevez scored a hat-trick two days after he was arrested as they cruised past Barnsley 5-0 to join history makers Wigan Athletic in the FA Cup semi-finals on Saturday.
Substitute Nani reminded manager Alex Ferguson of his qualities by inspiring Manchester United to a laboured 2-1 home win over Reading in the FA Cup fifth round on Monday.
Manchester City manager Pep Guardiola admitted he was surprised that Norwegian striker Erling Haaland declined to take a penalty for his side in Saturday's FA Cup final against Crystal Palace with the kick subsequently being missed by Omar Marmoush.
Chelsea manager Antonio Conte got the upper hand on Jose Mourinho for the second time this season as his double-chasing side beat 10-man Manchester United 1-0 at Stamford Bridge to reach the FA Cup semi-finals on Monday.
Vibrant Chelsea made it a torrid few days for Liverpool as goals by Willian and Ross Barkley sealed a 2-0 victory to send them through to the FA Cup quarter-finals on Tuesday. Liverpool's 44-match unbeaten streak in the Premier League ended in stunning fashion with a 3-0 defeat at Watford on Saturday and they were rocked again at Stamford Bridge.
Holders Chelsea came from two goals down to draw 2-2 with Manchester United on Sunday and earn a replay of their FA Cup quarter-final, inflicting further pain Alex Ferguson's side who have endured a week to forget.
Everton ended third-tier Oldham Athletic's giantkilling FA Cup run with a 3-1 victory in their fifth round replay on Tuesday to tee up an all Premier League quarter-final against Wigan Athletic.
A stunning strike from 18-year-old Curtis Jones gave a youthful Liverpool a 1-0 win over Everton in their FA Cup
The majority of Premier League clubs would prefer not to have the distraction of playing in the FA Cup, according to Paul Lambert, the manager of seven-time winners Aston Villa.
Two goals from late substitute Olivier Giroud and one apiece by Mesut Ozil and Mikel Arteta secured Arsenal's place in the FA Cup semi-finals with a 4-1 win against Everton at the Emirates Stadium on Saturday.
Last year's FA Cup runners-up Stoke City had a man harshly sent off but then scored a controversial penalty as they reached the quarter-finals with a 2-0 win at fourth tier Crawley Town on Sunday.
Premier League Hull City were given a fright as they had to come from behind twice to beat obstinate third tier side Sheffield United 5-3 in the FA Cup semi-final at Wembley on Sunday to reach the final for the first time.
Pictures on social media also appeared to show Nazi salutes being performed by supporters of Sydney United 58, who were founded as Sydney Croatia in 1958 and were a powerhouse in the National Soccer League that preceded the formation of the A-League in 2004.
Manchester United provided some blessed relief to under-fire manager Louis van Gaal by powering into the FA Cup quarter-finals with a 3-0 romp at League One (third-tier) Shrewsbury Town.
Holders Arsenal kept up their bid for a hat-trick of FA Cup trophies, marching into the quarter-finals as Olivier Giroud and Theo Walcott netted twice in a 4-0 replay win at second-tier Hull City on Tuesday.
A bemused Jose Mourinho described Chelsea's performance as unacceptable and a disgrace after the Premier League leaders slumped to a 4-2 home defeat against third-tier Bradford City in the FA Cup fourth round on Saturday.
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
News of all that's transpired on and off the football field
Sutton United's FA Cup fairytale ended as Arsenal forward Theo Walcott scored his 100th goal for the club in a 2-0 fifth round victory on a surreal night at Gander Green Lane on Monday.
Left-back Saka and striker Eddie Nketiah netted inside 26 minutes as Arsenal's much-changed lineup made a dominant start
Kevin de Bruyne's first-half penalty and a superb strike by Raheem Sterling after the break earned holders Manchester City a comfortable 2-0 away win at Newcastle United in the weekend's last FA Cup quarter-final on Sunday.
Premier League leaders Manchester City recovered from two goals down to beat Championship side Swansea City 3-2 at the Liberty Stadium on Saturday and progress to the FA Cup semi-finals.
Bodo/Glimt secured an upset 3-1 victory over Serie A leaders Inter Milan in the first leg of their Champions League playoff on Wednesday.
Manchester City to beat second-tier Sheffield Wednesday 1-0 and reach the FA Cup quarter-finals but Jose Mourinho's problems piled up as his Tottenham Hotspur side were bundled out in a penalty shootout by Norwich City.
'We changed our attitude, desire and organisation at halftime and then we were completely different. It was good for my players to learn and to suffer on the pitch'
Manchester City rediscovered their swagger to beat Chelsea 2-0 and move into the quarter-finals of the FA Cup on Saturday, Manuel Pellegrini winning the battle of tactical wits against Jose Mourinho.
Arsenal's miserly defence has conceded three Premier League goals so far this season and manager Mikel Arteta hopes their fortress-like foundation can finally deliver the silverware that has eluded the North London club for so long.
News of all that's transpired on and off the football field
Alan Pardew's dream of reprising a celebrated 25-year-old FA Cup triumph was scuppered by Liverpool as the seven-times champions came from behind to book a place in the quarter-finals with a 2-1 win at Crystal Palace on Saturday. This year's shock-laden competition had continued with second-tier Blackburn Rovers' 4-1 thrashing of the Premier League's Stoke City.
Premier League leaders Arsenal host north London rivals Tottenham Hotspur in the standout tie in the draw for the third round of the FA Cup made on Sunday.
Wigan, who had beaten three Premier League teams in the Cup including Manchester City in the previous round, could not convert their chances, however.
Arsenal denied Chelsea the double with a 2-1 victory in an enthralling FA Cup final.
FA Cup holders Arsenal have been drawn against runners-up Hull City, a repeat of last year's enthralling final, in this season's third round after the draw was made on Monday.